The Endocannabinoid System (ECS)

The endocannabinoid system (ECS) is a complex intracellular communication system. The ECS communicates with the brain, organs, and tissues. It balances and stabilizes activities within the human body. It is vital to overall health, as it maintains internal homeostasis, our state of balance.

Cannabinoids May Have a Role in Regulating:

Appetite
Cognition
Immunity
Memory
Mood
Movement
Pain
Reproduction & Fertility
Sleep
and more!

ECS Receptors

The ECS is composed of receptors, endocannabinoids, and enzymes. These unique receptors can be found all over the body. CB1 and CB2 receptors are located throughout the body but more densely in certain areas. CB1 receptors are mostly found in the brain and nervous systems. CB2 receptors are mostly found in peripheral organs and cells related to the immune system.

Three Sources of Cannabinoids

Lock & Key Mechanism

Like a lock and key, receptors in the ECS are primarily made to connect with one endocannabinoid. Phytocannabinoids are structured similarly to our endocannabinoids; they are able to unlock these receptors. When they connect, they can cause changes within in the body.

Anandamide (ANA) and 2-Arachidonoylglycerol (2-AG) are endocannabinoids and neurotransmitters. THC is similar to ANA, also known as AEA. CBD is similar to 2-AG. For example:

Phytocannabindoids

ECS receptors can receive phytocannabinoids found in the cannabis plant. That means our bodies can utilize these plant-based compounds.

CBD

CBD does not bind to the CB1 & CB2 receptors. Rather, it modifies the ability to bind to cannabinoids and enhances natural levels of endocannabinoids.